Do not attempt to accurately dose smaller dogs through the use of breaking larger tablets. Postoperative Orthopedic Pain and Inflammation: 1.4 – 1.8 mg/lb/day (3 to 4 mg/kg/day) as a single daily dose, as needed, not to exceed 7 days of administration.ĭogs needing a dose of less than 12.5 mg can only be accurately dosed through use of the 12 mg tablet, which can be broken in half to provide 6 mg. Postoperative Orthopedic Pain and Inflammation:ĭeramaxx Chewable Tablets are indicated for the control of postoperative pain and inflammation associated with orthopedic surgery in dogs. Inaccurate dosing may result in adverse drug events (see Adverse Reactions, Animal Safety, and Post-Approval Experience). Osteoarthritis Pain and Inflammation: 0.45 – 0.91 mg/lb/day (1 to 2 mg/kg/ day) as a single daily dose, as needed.ĭogs needing a dose of less than 12.5 mg can only be accurately dosed through use of the 12 mg tablet, which can be broken in half to provide 6 mg. Use the lowest effective dose for the shortest duration consistent with individual response.ĭeramaxx Chewable Tablets are indicated for the control of pain and inflammation associated with osteoarthritis in dogs.
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Carefully consider the potential benefits and risk of Deramaxx and other treatment options before deciding to use Deramaxx. Indications and Usage:Īlways provide “Information for Dog Owners” Sheet with prescription. No statistically significant differences between genders were observed. Large intersubject variability was observed in drug metabolite profiles of urine and feces. The majority of deracoxib is excreted in feces as parent drug or metabolite. The major route of elimination of deracoxib is by hepatic biotransformation producing four major metabolites, two of which are characterized as products of oxidation and o-demethylation. Non-linear elimination kinetics are exhibited at doses above 8 mg/kg/day, at which competitive inhibition of constitutive COX-1 may occur.ĭeracoxib is not excreted as parent drug in the urine. Summary pharmacokinetics of Deramaxx tablets are listed in Table 1.ĪValues obtained following a single 2.35 mg/kg doseīEstimates following IV administration of deracoxib as an aqueous solutionĬBased upon a dose of 2 mg/kg of deracoxibĭBased upon in vitro plasma concentrations of 0.1, 0.3, 1.0, 3.0, 10.0 μg/ml 6 The clinical relevance of this in vitro data has not been shown.Īlthough the plasma terminal elimination half-life for Deramaxx tablets is approximately 3 hours, a longer duration of clinical effectiveness is observed. 5 At doses of 2-4 mg/kg/day, Deramaxx tablets do not inhibit COX-1 based on in vitro studies using cloned canine cyclooxygenase. 4 Both COX isoforms are constitutively expressed in the canine kidney.
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3 Cyclooxygenase-2 (COX-2) is responsible for the synthesis of inflammatory mediators. 2Ĭyclooxygenase-1 (COX-1) is the enzyme responsible for facilitating constitutive physiological processes (e.g., platelet aggregation, gastric mucosal protection, renal perfusion). 1 Deracoxib inhibited COX-2 mediated PGE2 production in LPS-stimulated human whole blood. The structural formula is:ĭeramaxx tablets are a member of the coxib class of non-narcotic, non-steroidal, cyclooxygenase-inhibiting anti-inflammatory drugs for the control of postoperative pain and inflammation associated with orthopedic and dental surgery and for the control of pain and inflammation associated with osteoarthritis in dogs.ĭata indicate that deracoxib inhibits the production of PGE1 and 6-keto PGF1 by its inhibitory effects on prostaglandin biosynthesis. Deracoxib is 4- benzenesulfonamide, and can be termed a diaryl substituted pyrazole. The empirical formula is C17-H14-F3-N3O3-S. The molecular weight of deracoxib is 397.38.
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Deramaxx tablets are round, biconvex, chewable tablets that contain deracoxib formulated with beefy flavoring. Description:ĭeramaxx (deracoxib) is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) of the coxib class. Federal Law (U.S.) restricts this drug to use by or on the order of a licensed veterinarian.